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In addition, the gut microbiota was found to influence the process of monocyte migration from the periphery to the brain mediated by TNF-, which was reversed by the use of probiotics (119)

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Activated charcoal can be used to try to reduce the absorption of acetaminophen if the patient presents within one hour of the ingestion.9 Otherwise, the treatment of choice is use of a specific antidote, N-acetylcysteine, which reduces the hepatotoxic effects of acetaminophen overdose by replenishing glutathione stores, thereby enhancing production of the nontoxic metabolites

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Peer review Peer review information Nature Communications thanks Robert Ellingford, Jerilynn Prior, and the other, anonymous, reviewers for their contribution to the peer review of this work