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10.1016/j.freeradbiomed.2013.07.039 63 LeiP.BaiT.SunY

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Because tumors grow faster than blood vessels can form, cancer cells close to blood vessels receive oxygen and are therefore normoxic, while those farther from blood vessels lack sufficient oxygen supply and are hypoxic

248 Overall, lactate creates an immune-permissive environment for tumors by modulating the NF-B pathway, enhancing their ability to evade immune surveillance