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10.3390/ijerph191610429 260

For example, proinflammatory cytokines such as IL-1 have been shown to impair neurotransmitter homeostasis (e.g., decreased serotonin levels and enhanced glutamatergic excitotoxicity), induce oxidative stress (OS) and neuronal pyroptosis, and lead to mitochondrial dysfunction and synaptic protein lossultimately fostering a bidirectional relationship between epilepsy and depression (Zhu et al., 2006

discovered that the mA demethylase ALKBH5 delays the progression of diabetic retinopathy by inhibiting ferroptosis via the mAYTHDF1ACSL4 axis, suggesting its potential as a therapeutic target [169]

The homogenate was centrifuged at 13,000 g for 20 min at 4 C, and the supernatant was used for antioxidant enzyme assays

Link Cournoyer, J