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Body weight increased 0.8 kg in the placebo group and 2.7 kg in the MK-677 group

Immune & Inflammatory Research: KPV-related inflammatory-response signaling, epithelial immune communication, and immune pathway modulation

What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug

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We used the Schrodinger software to perform induced-fit docking of chemical compounds to protein receptors 64