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The documented doses, such as 0.01 to 1 mg/kg intravenously in animal models or 0.03 mg/kg intravenously in the clinical ileus study, are pure study parameters and serve to describe the state of research

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You can read the abstract of this article at Dobs AS, Boccia RV, Croot CC, Gabrail NY, Dalton JT, Hancock ML, Johnston MA, Steiner MS

However, medical supervision and regular monitoring are important due to the limited availability of long-term safety data