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The cases of hereditary occurrence of CRC constitute only about 5% [28]

For example, under continuous infusion pump drive, the release rate remains stable (e.g., morphine delivery, with a release error of less than 5% over 24 h) [89]

Garibotto, G

Thus, considering also the natural inhibition of endocytosis in the BBB barrier, it is possible that early in infection, only a few meningococci can cross the barrier through the transcellular route