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The challenges in preclinical studies and clinical trials, and the implications of these targeted pharmacological treatments for other ASDs and related neurodevelopmental disorders are also discussed

Added pounds and inactivity can aggravate symptoms of other conditions such as diabetes and high blood pressure

doi: 10.1371/journal.pone.0082485 141 SalehiH.BahramnejadB.MajdiM

100 The brain and spinal cord are protected by highly selective barriers that, while essential for maintaining neural homeostasis and protecting against pathogens, limit the penetration of potentially beneficial therapeutic compounds