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5 Epigenetic studies have shown methylation changes in genes involved in neurotransmission and energy metabolism, suggesting that environmental and developmental factors may influence ADHD risk by altering protein expression and metabolic pathways, connecting gene regulation to proteomic and metabolomic signatures .11 Emerging reviews indicate that such integrative multi-omics designs are increasingly being used across neurodevelopmental disorders, including ADHD

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43,356 Moreover, long-term follow up data from patients with type 1 and type 2 diabetes have confirmed that hyperglycemia is a risk factor for CVD