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IFN- has been detected to upregulate the expression of OTUD5 through p38-dependent mechanism to amplify the aberrant inflammatory cytokine response in IBD (Dinallo et al., 2022)

Increased production of tumour necrosis factor-alpha interleukin-1 beta, and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohns disease

The above research results suggest that m6A modification may be closely related to the occurrence and development of ferroptosis in AD and requires further in-depth research for verification

Immunofluorescence staining was performed to assess macrophage polarization, with CD86 serving as a marker for pro-inflammatory M1 macrophages and CD206 for anti-inflammatory M2 macrophages

At a cellular level, IF stimulates autophagy, promoting the clearance of damaged proteins and organelles and reducing oxidative stress within the gastrointestinal tract [73]