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Pro-inflammatory cytokines induce signaling cascades that can lead to downregulation of stabilizing factors such as sonic hedgehog [3, 58], to activation of effector proteins such as matrix metalloproteinases [33], and to the formation of reactive oxygen species [47]

Rat Two- and eighteen-month-old adult lean SpragueDawley rats ( n = 12

It helps clear glucose from the blood and shuttles it into muscle cells where it can be used for energy

Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation

To elucidate the involvement of RGMa in the neural differentiation of NSCs, we cultured neurospheres, which are clusters composed of NSCs from neurogenic niches, as described previously 35,36 (Fig