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We are thankful to Katya Sverdlov for coordinating the study

Immunity 16(6):76977 [DOI] [PubMed] [Google Scholar] 51.Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, et al

Cross-age comparisons show that the genetic structures of pediatric and elderly IBD exhibit a bipolar differentiation VEO-IBD has the heaviest genetic burden: more than one-third of those with onset before age 6 carry single-gene defects, IL-10R mutations can be cured through hematopoietic stem cell transplantation [203,204,205], NOD2 biallelic mutations often lead to stricturing CD and high surgery rates [206],and rare defects such as lipopolysaccharide-responsive beige-like anchor protein (LRBA) and syntaxin-binding protein 2 (STXBP2) are also frequently observed [206, 207]

These compounds are celebrated for their wide-ranging advantages, spanning from the reduction of blood pressure to a lowered risk of chronic diseases such as cancer and diabetes

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