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239 , 240 , 241 Several underlying mechanisms have been suggested and described, for example, the decrease in lowgrade chronic inflammation, modulation of cytokine microenvironment, restoration of the antioxidant mechanisms, improvement in immune defense against pathogens, increase in telomerase length and activity, modulation of cytokine signaling, and increase in autophagyinduced mitochondrial functions

When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells

This weight gain effect is related to the increase in GH levels but may also be linked to the appetite-stimulating impact of ghrelin receptor activation [14]

2F, the changes in the absorbance max peak wavelength as a function of the denaturation times are displayed

doi: 10.3389/fmicb.2021.772420 90 LimC