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During dialysis, patients experience subnormal plasma/serum free carnitine concentrations [13] with plasma levels dropping by 60% with a slow replacement from carnitine stores such as from skeletal muscle during the interdialytic period

Similarly, administration of metformin, the main first-line medication for the treatment of type 2 diabetes, reduces muscle wasting in tumor-bearing rats (Oliveira and Gomes-Marcondes, 2016), but metformin induced opposite results in a phase-2 trial (Kordes et al., 2015)

Davenport, A

Pulmonary hypertension in late-onset methylmalonic aciduria and homocystinemia: a case report