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But the most significant outcomes in peptide therapy come from combining peptides that target complementary biological pathways creating synergistic effects that exceed what any single peptide achieves alone

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However, the foundational mechanism paper (Benoist et al., 2014 in J Pharmacol Exp Ther) establishing Dihexas HGF/c-Met pathway activation was formally retracted in April 2025 after being flagged since 2021