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The benefits and drawbacks of glutathione IV include rapid peak concentration within minutes, skin improvement in 37.5% of participants versus 18.7% placebo, and FDA approval as chemotherapy adjunct, while risks encompass adverse events in 32% of users, lack of FDA approval for skin lightening, and benefits fading after 6 months of discontinuation

In investigating the neurological and cognitive functions of aged mice in a study focused on the auditory cortex, the effect of alleviating ferroptosis in the brain was achieved by treatment with DFO, suggesting that DFO may be used to treat auditory and cognitive impairment resulting from age-associated problems (169)

FM presents with functional and structural alterations in the CNS, particularly affecting the brain regions involved in pain processing [68, 69]

Their findings demonstrated that nicotine impairs wound healing by increasing ROS and inhibiting cell migration by reducing RacGTP levels

2 School of Natural Medicine, Faculty of Community and Health Sciences, University of the Western Cape, Bellville, South Africa