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doi: 10.1038/s41561-018-0080-1 248 HwangG.-J.XieH.WahB

Although HO-1 is commonly associated with cytoprotection and inhibition of cell death processes, excessive activation of HO-1 releases large amounts of Fe 2+ , leading to the accumulation of unstable iron pools and corresponding deleterious cyclic effects that exacerbate oxidative stress, presenting a dual effect that characterizes HO-1 as a double-edged sword

For instance, USP7 contributes to chemoresistance in cervical cancer by maintaining the stability of the Chk1 protein and reducing DNA damage responses

These proteins play an important role in DNA damage repair, autophagy, apoptosis, energy metabolism, inflammatory response and mitochondrial health

Xian ZY, Hu B, Wang T, Cai JL, Zeng JY, Zou Q, et al