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The peptide's documented interaction with dopamine D2 receptors, including attenuation of amphetamine-induced hyperlocomotion and modification of haloperidol-induced catalepsy, suggests it could modulate the effects of dopamine agonists (pramipexole, ropinirole) or antagonists (antipsychotics) 4

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Thymosin beta-4 is a defined 43-amino-acid endogenous protein, while TB-500 is usually a synthetic fragment built around its actin-binding domain (Ac-LKKTETQ)