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As part of the Pediatric Preclinical Testing Program (PPTP), 2 astrocytoma cell lines were generated, BT-35 cells which had 2 to 5 copies of wild-type (WT) BRAF and BT-40 cells which had 5 copies of activated BRAF V600E [ ( Table 2 )]

Treating one without addressing the other produces incomplete results

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