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Additionally, alignment to the central helical Z -axis and a simple morph of the global basal and activated models show that the large conformational change is possible in the filament with fewer clashes when the CD moves in concert with the RDs (Supplementary Fig

Micu et al., 2016, 2018), oxidative stress (Cheignon et al., 2018), mitochondrial impairment (de la Cueva et al., 2022) (well documented in the MS brain

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made it more paradoxical as they reported that carnitine supplementation could significantly lessen both the fatigue severity scale and mental fatigue score of hypothyroid patients younger than 50 years of age, and thus they concluded that carnitine supplementation may be useful in alleviating fatigue symptoms in this group [31]

Nature 420:520562 Wilber A, Frandsen JL, Geurts JL, Largaespada DA, Hackett PB, McIvor RS (2006) RNA as a source of transposase for sleeping beauty-mediated gene insertion and expression in somatic cells and tissues