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Description

The garlic compound Z-ajoene, S-thiolates COX2 and STAT3 and dampens the inflammatory response in RAW264.7 macrophages

The absence of the long-chain PUFA ligases ACSL4 and LPCAT3, which are responsible for re-esterifying AA into lysophospholipids, impedes the synthesis of PE-AA, thereby significantly increasing cell resistance to ferroptosis (Zheng and Conrad 2020)