doi: 10.1016/J.TOX.2004.01.008 123 de MarcoRPoliAFerrariMAccordiniSGiammancoGBugianiMet al
Vitamin B5 deficiency is extremely rare, because this vitamin is present in nearly all foods [20]
some PFIC types have been described as at risk of liver cancer development
Supplementary Table 5 (download XLSX Investigated_Drug_MoA (Names of all MoA classes with more than five drugs, area under the curve values from ROC curve analysis, number of drugs in the MoA Class, drug names) / t-test_p-values ( P values per metabolite and MoA class from t -test comparing drugs of an MoA class to all other drugs) / mean_zscores_metabolites (mean z-score per metabolite across all drug perturbations of an MoA class) / PEA_p-values ( P values per metabolic pathway (KEGG) and MoA class from pathway enrichment analysis (PEA) using all drugs from an MoA) / PEA_q-values ( q values per metabolic pathway (KEGG) and MoA class from PEA using all drugs from an MoA) / mean_ zscores_pathways (mean z-score per metabolite pathway across all drug perturbations of an MoA class) / median_zscores_pathways (median z-score per metabolite pathway across all drug perturbations of an MoA class)
For example, simultaneously evaluating the expression, enzyme activity, and lipidomic characteristics of GPX4, SLC7A11, ACSL4, LPCAT3, FSP1, and DHODH in the same batch of patient tissues, combined with disease staging and tissue-specific differences between cartilage and synovium, can clarify the dominance of each pathway at different stages
