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Several factors can contribute to the onset of toe cramps, including overexertion during physical activities, prolonged periods of sitting or standing, and even wearing ill-fitting shoes

-Cells contain ATP-sensitive potassium channels, which open at low levels of glucose but close when glucose is elevated

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A single overdose is typically not dangerous but may cause increased nausea, vomiting, or other GI side effects

Acknowledgments We would like to thank Professor Jianye Dai (Faculty of Pharmacy, Lanzhou University) and Professor Bin Luo (Faculty of Public Health, Lanzhou University) for help in quality of figures and article structure