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Among the environmental factors, cigarette smoke has been shown to produce damaging effect on RPE, such as sub-RPE deposits, oxidative damage, and apoptosis of RPE (Espinosa-Heidmann et al., 2006

24, 25 It has been proposed that variations in the 3-untranslated region of the GPX4 gene can influence the position of GPX4 in the hierarchy of demands on the components of the selenoprotein-synthesis apparatus, with consequent effects on the synthesis of other selenoproteins

10.1523/JNEUROSCI.3003-04.2005 100 WinterS.BrunkI.WaltherD

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