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10.1016/j.freeradbiomed.2018.05.093 52

Because of this rapid degradation, it was widely believed that oral glutathione had extremely poor bioavailability (often estimated at less than 5%) and could not effectively raise systemic intracellular stores

Administered at 918 g/kg/day, XFZYD upregulated NMADR1, CaMKII, and GAP-43, effectively improving neurological deficits and cognitive impairments (Zhou et al., 2017)

N Engl J Med 331 (13): 828-35, 1994

Moreover, this reinforces the fact that GSH depletion modulates only physiological relevant stimuli as P 2 Y receptors activation and oxidative stress