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7.1.3 mTOR inhibitors The mTOR inhibitors are the most extensively studied targeted therapies for the PI3K-AKT-mTOR signaling pathway and were the first to enter clinical practice (233)

Inupakutika et al

doi: 10.3389/fimmu.2016.00680 155 KhaderSADivangahiMHanekomWHillPCMaeurerMMakarKWet al

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That initial discoverywhere dialysate from sleeping rabbits actually triggered sleep in recipient animalskicked off decades of study into how this peptide helps regulate sleep cycles