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The grid point spacing on the lower edge of the face is set at 1.0 cm

If detected soon after birth, the condition can be treated simply with oral doses of thyroid hormone to permit normal development

Gonzalez-Freire M, Diaz-Ruiz A, Hauser D, Martinez-Romero J, Ferrucci L, Bernier M, de Cabo R (2020) The road ahead for health and lifespan interventions

doi: 10.1038/s41374-021-00667-6 134 PiaskowskiSBienkowskiMStoczynska-FidelusEStawskiRSierutaMSzybkaMet al

2 Materials and methods 2.1 APAP overdose and clinical data To demonstrate the in silico dose-dependent variability, APAP overdose clinical data were obtained from the hepatotoxic study published by Patient A: Low overdose: 6.1 g of APAP, 3.9 days since APAP intake