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To address this, we performed an unbiased interaction screen for interactors of the APP cytosolic tail

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In addition, the increase in the phosphorylation of p38 MAPK was not statistically significant (Figure 6)

Such a combinatorial form of metabolic regulation employing both elements of lactic acidosis would in theory limit a glycolytic flux preventing further glucose fermentation in the direction of lactate production thus intercepting glycolytic intermediates