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Subcutaneous administration near the injury site provides both high local concentration and some systemic distribution as the peptide migrates to areas of damage throughout the body

This potential action appears linked to VEGFR2-related pathways, which are involved in nitric oxide signaling and endothelial cell activity

10.1016/j.bmcl.2017.07.013 Summary Keywords docking, MD simulations, pharmacophore, acetylcholinesterase, machine learning Citation Hayek-Orduz Y, Acevedo-Castro DA, Saldarriaga Escobar JS, Ortiz-Domnguez BE, Villegas-Torres MF, Caicedo PA, Barrera-Ocampo , Cortes N, Osorio EH and Gonzlez Barrios AF (2025) dyphAI dynamic pharmacophore modeling with AI: a tool for efficient screening of new acetylcholinesterase inhibitors

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Authors : Yi Wen, Deven Lemen, Yanzhu Lin, Yan Q Chen, Ajit Regmi, William C Roell, Melissa K Thomas, Mark L Hartman, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Giacomo Ruotolo, Robert J Konrad Source : This study investigated the effect of Retatrutide on circulating concentrations of the angiopoietin-like protein 3/8 complex (ANGPTL3/8) and its relationship with serum lipid levels