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Similarly, yak1 cells showed increased cytosolic pH, suggestive of an absence of Cys4p activity as shown by CYS4- OE in a yak1 strain was unable to induce cytoplasmic acidification defects and even further accentuated cytosolic pH basification (Figure 1G)

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Consistently, combination therapy with bevacizumab, a VEGF inhibitor, and erlotinib, an EGFR inhibitor has been proposed [117]

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L'intoxication au paractamol constitue la dmonstration clinique la plus directe du rle protecteur du glutathion hpatique