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Research Applications Preclinical research has demonstrated that NNMT inhibition with 5-Amino-1MQ reduces adipogenesis, decreases fat cell size, and increases resting metabolic rate in animal models without significant toxicity

Njalsson, R., Ristoff, E., Carlsson, K., Winkler, A., Larsson, A

The pathogenesis of hyperuricemia is primarily delineated into two pathophysiological mechanisms: hyperproduction of uric acid and defective renal excretion

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These findings contribute to a better understanding of the molecular mechanisms underlying iron toxicity in kidney cells and suggest that the molecules in the ferroptosis pathway are potential therapeutic targets to mitigate iron-induced renal damage