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thaliana leaves, virus replication levels were also higher in an SA-deficient NahG biotype than in wild type Col-0 plants during the first 10 days of infection, while SA-deficient plants displayed lower virus titers than the wild-type seedlings at 20 and 25 days post-inoculation, indicating a possible adaptation of SA-deficient plants to virus infections in later stages of pathogenesis ( Figure 2 ), perhaps reflecting a similar adaptation process

189,190 The invasive potential of these cells is driven by upregulated signaling pathways, including L1CAM, ephrin-B2, 191 and epithelialmesenchymal transition (EMT)-associated factors such as twist-related protein 1 (TWIST1), SOX2, and signal transducer and activator of transcription 3 (STAT3)

Though they participate in the uptake process, their role in drug disposition is not yet understood (van de Steeg et al., 2012