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In addition, DUSP1 overexpression induces the nuclear translocation of the AMPK activator-LKB1 (also known as STK11) in human HepG2 hepatocytes [152]

For example, in pulmonary MVECs exposed to chronic IH, ROS production increased and was associated with endothelial barrier dysfunction due to ROS-dependent activation of extracellular signal-regulated kinases (ERK) 1/2 and c-Jun N-terminal kinases that initiate the reorganization of cytoskeletal and junctional proteins [154]

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doi: 10.1111/j.1582-4934.2004.tb00275.x

About 90% UA is reabsorbed into blood (Jessica Maiuolo et al., 2016)