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However, if factors such as the prescribed medications are negatively impacting B12 status then the frequency may well need to be increased to either 6-monthly or 3-monthly

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Proc Natl Acad Sci U S A 100:35253530 Chen Z, Gallie DR (2005) Increasing tolerance to ozone by elevating foliar ascorbic acid confers greater protection against ozone than increasing avoidance