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Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death

Furthermore, NAC has both direct and indirect antioxidant properties, which have been extensively assessed in in-vitro and in-vivo studies

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma

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