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Description

Of the seven PDX exposed to IACS, five responded with tumour regression or stable disease, whereas two were resistant (Fig

Hasegawa T, Iino S, Kitakaze K, Kato T, Kabata D, Oyama N

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice

Furthermore, the paper explores how these regulatory mechanisms affect NRF2s roles in oxidative stress, inflammation, and cell death, identifying novel therapeutic targets and strategies