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At the molecular level, Tat upregulates miR-34a, which suppresses CARD-containing adaptors and increases NF-B p65, thereby augmenting NF-B signaling and triggering a pro-inflammatory microglial response that contributes to neuroinflammation [111] (Fig

Results Characterization of repRNA encoded gH/gL and gH/gL/gp42 To enable co-delivery of both gH and gL or gH, gL, and gp42 on a single repRNA, we designed two constructs

The stem cell niches, including extracellular matrix (ECM), cell-to-cell communication, cytokines, and growth factors, etc, provide structural support as well as appropriate physiochemical, biophysical, and biochemical cues that ultimately govern MSC behavior and fate

The resulting films were analyzed to assess their structural and thermal properties, and the gas permeation changes due to their temperature-responsive behavior

Volz A-K, Dingemanse J, Krause A, Lehr T (2019) Target-mediated population pharmacokinetic modeling of endothelin receptor antagonists