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Most MS patients, over time and aging, switch to a progressive phase characterized by a gradual clinical decline with progressive deterioration of neurological functions, due to continuous axonal degeneration ( The mechanism of MS pathology involves complex interactions between systems and cell types, such as neurons, glia, and immune cells, which lead to focal lesions of inflammatory demyelination and widespread neurodegeneration in the brain and spinal cord

Nature 472 , 486490 (2011)

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Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (Rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders , vol