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Liu J, Wang Z, Mai P, Hao Y, Wang Z, Wang J

Agric Biol Chem 52 , 95-98 (1988)

www.clinicalpharmacology.com

10.1016/j.ccmp.2024.100129 104 MlhoptS.DiabatS.DilgerM.AdelhelmC.AnderlohrC.BergfeldtT.et al (2018)

The activity of surrounding immune cells is suppressed by ROS and, therefore, loss of ATM and the associated increase in ROS production may facilitate immune evasion.48 Finally, loss of ATM and the associated decrease in antioxidant levels may render the tumor cells more dependent on stromal cells for redox support,49 thus providing a rationale for combined therapeutic approaches with pro-oxidants and inhibitors of tumor/microenvironment interactions