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Description

The Notch pathway inhibitor stapled alpha-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma

Results Across mechanistic endpoints, LC was associated with reductions in inflammatory markers, oxidative stress indices, and cardiac injury biomarkers, with several trials noting improvements in left-ventricular function and lipid profiles

10.1186/s12933-019-0879-0 Summary Keywords mitoepigenetics, mtDNA, ncRNAs, mitochondria, aging, cardiovascular diseases, methylation Citation Mongelli A, Mengozzi A, Geiger M, Gorica E, Mohammed SA, Paneni F, Ruschitzka F and Costantino S (2023) Mitochondrial epigenetics in aging and cardiovascular diseases