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~ AlphaMD Most men on testosterone replacement therapy expect to feel like a new person, and many do, until they notice that sleep is still broken, mornings still feel heavy, and something they can't quite name is still missing

Release of microvesicles and nanovesicles from aging RBC It is known for many years that senescent RBC are smaller, denser than young cells and have lost membrane and hemoglobin

The two cell theory explains that ovarian steroidogenesis is regulated by consequent and mutually dependent processes (40), where LH stimulates theca cells to produce androgens, which are converted to various estrogens by the aromatase enzyme expressed in granulosa cells under the induction by FSH (40)