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Excessive accumulation of NAPQI depletes hepatic GSH stores, leading to oxidative stress, mitochondrial dysfunction, and covalent modification of cellular macromolecules

Low NAD+ levels can be caused by deficiencies in the synthesis/salvage pathways, excessive DNA damage from free radicals or ultraviolet light, or chronic immune activation

Studies showed that EGCG inhibited the methylation of WIF-1 in lung cancer cells (Gao et al., 2009) and GSTP1 in prostate cancer cells (Pandey et al., 2010)

The peptide exhibits efficacy across various administration routes including local application at the injury site, systemic intramuscular injection, and oral delivery

Disruption of this regulatory axis perturbs energy balance and compromises metabolic homeostasis