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Future research should focus on randomized trials, biomarker stratification, and combining KDs with metabolic therapies like -hydroxybutyrate to establish KD as a standard cancer treatment (Table 4)

The dosage levels used in research vary from 10 g/kg to 1 mg/kg depending on the study

Aarsaether, E., Rydningen, M., Einar, R., et al

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Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: involvement of PI3K/Akt and MAPK signaling pathways