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Data resources used in this study are: hg38 genome FASTA ( CHIKV genome FASTA & annotation ( and DENV-2 genome (strain 16681) FASTA & annotation ( Site-directed mutagenesis (SDM) A single point mutation to mutate the DENV-2 motif 8 AAACA (92919295) into AAATA in the DENV-2 wild type plasmid (pFK-DVs) was generated using QuickChange XL site-directed mutagenesis kit (Agilent, 200517) according to the manufacturers instructions