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Type 2 diabetes with neuropathy: Forty-eight patients with moderate to severe small fiber neuropathy-induced chronic pain received daily subcutaneous injections of ARA-290 at 4 mg or placebo for 28 days

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[1] Some compounders suggest adding B12 to tirzepatide formulations based on theoretical concerns about vitamin B12 absorption, though it's important to note that clinical evidence specifically linking tirzepatide to B12 deficiency is lacking

Nutrient toxicity (only a risk if IV therapy is administered without blood monitoring)

Angiogenesis signaling: Studied for its role in microcirculation and blood vessel response in damaged tissue models