Only use the dose that is suggested, as an overdose can lead to high blood calcium levels (hypercalcemia), kidney stones and skeletal abnormalities
Study population LARC within 12 cm from anal verge MRI-confirmed uninvolved MRF Median follow-up 48 months Treatment strategy CAPOX x4 cycles surgery Pelvic RT + capecitabine surgery Key 3-year outcomes LRRFS 97.4% (CRT) vs 96.3% (CAPOX) | HR 1.40 DFS 89.2% vs 87.9% | HR 0.88 OS 95.0% vs 94.1% | HR 0.86 Long-term toxicity matters Grade 2-4 late AEs 26.3% (CRT) vs 16.0% (CAPOX) Chronic proctitis 41.7% vs 33.6% Clinical interpretation Non-inferiority was not formally met due to extremely low event rates
Without this active form of B12, homocysteine cannot fully recycle back to Methionine nor go down the transsulfuration pathway to become glutathione
A 2021 retrospective study examined knee injections in 16 patients with various types of knee pain
10.1093/jn/nxy119 Summary Keywords high-fat and high-cholesterol diet, ketogenic diet, spermatogenesis, oxidative stress, apoptosis Citation Liu C-Y, Chang T-C, Lin S-H and Tsao C-W (2022) Is a Ketogenic Diet Superior to a High-Fat, High-Cholesterol Diet Regarding Testicular Function and Spermatogenesis