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Signaling mediated by these receptors leads to the activation of Rac1, a GTPase of the RHO family, which regulates the polymerization and reorganization of the actin cytoskeleton in phagocytes, facilitating the formation of the phagocytic cup, the internalization of the apoptotic body and the formation of the phagosome - in a process mediated by the protein complexes LRP1-GULP and ELMO-DOCK, responsible for the activation of Rac1 [12, 13]

Intrathecal drug delivery in the era of nanomedicine

These findings indicate a kinetic effect of the FAT10 UBL2 domain on the rate-limiting step during initiation rather than a contribution to the binding affinity