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Although these data suggest that GSH depletion per se, at least for a short period of time, is not sufficient to cause cell injury, a prolonged depletion of mucosal GSH leads to severe degeneration of intestinal mucosal epithelial cells, as shown in BSO-treated mice (Martensson et al, 1990)

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Therefore, individuals who consume alcohol heavily should ensure adequate thiamine supplementation before and during ALA therapy

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In one randomized trial, patients who used WBV for several weeks reported less pain and better scores on neuropathy tests (Jamal et al., 2019)