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Treatment of mental health in patients with chronic liver disease

10.1016/j.bmcl.2009.07.068 Bioorg

Expect body-composition shifts over months, not dramatic weight loss

Reuben A, Zhang J, Chiou SH, Gittelman R, Li J, Lee WC, Quek K, Fujimoto J, Wang C, Behrens C, Kheradmand F, Chen R, Chow CW, Bernatchez C, Jalali A, Xin H, Wu CJ, Eerovic A, Parra E, Yusko E, Emerson R, Benzeno S, Vignali M, Wu X, Ye Y, Little L, Gumbs C, Mao X, Song X, Tippen S, Thornton R, Cascone T, Snyder A, Wargo J, Herbst R, Swisher SG , Kadara H, Moran C, Kalhor N, Zhang J, Scheet P, Vaporciyan AA, Sepesi B, Gibbons D, Robbins H, Hwu P, Heymach J, Sharma P, Allison J, Baladandayuthapani V, Lee J, Davis M, Wistuba I, Futreal PA, Zhang J

Researchers suggest that elevated gut pH, gut dysbiosis (i.e., a higher Firmicutes : Bacteroidetes ratio), obesity, or malabsorption might increase fecal SCFA, such as butyrate, which could have potential neurotoxic effects [25, 45, 46]