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Description

The data representing turnover numbers in min 1 have been extracted from the following references: a (Dixon et al., b (Dixon and Edwards, 2010b)

Supplementation with mevalonate (MVA) fully, and with GGPP partially, reversed simvastatin-induced ATF4 expression (Figure 1I) and rescued the cell growth inhibition by simvastatin (Figure S1D), confirming that these effects arise from blockade of the mevalonate pathway rather than a nonspecific effect of statins