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Approximately half of the trial participants had a history of psychiatric disorders, either past and in remission or present and clinically stable

Pregnant cases with HDP diagnoses maintained higher UA concentrations across early to mid-gestation compared to normotensive controls

Interestingly, the opioid antagonist naloxone can block some of DSIPs effects, confirming this opioid system involvement

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It rests on the observation that the two compounds act on different sides of the energy balance equation, on different mechanisms, with non-overlapping side-effect profiles, and that the bottlenecks in the GLP-1 plateau are bottlenecks the GLP-1 medication does not directly address